Journal of Current Chronic Diseases

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Current Chronic Diseases -Inflammatory mechanism of pathogenesis in neurodegenerative diseases-Yi Sui

China

Shenyang First People's Hospital,
Shenyang Brain Institute.

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Yi Sui

Address:

Shenyang First People's Hospital,
Shenyang Brain Hospital,
Shenyang Brain Institute,
67 Qingquan Rd,
Dadong District,
Shenyang,
Liaoning Province 110041,
China.

Research Interests:

Inflammatory mechanism of pathogenesis in neurodegenerative diseases, chemokine-induced pathogenesis and chemokine-regulated neurogenesis in neurodegenerative diseases.

Biography:

  • I have graduated from Dalian Medical University, China with a MBBS degree.
  • After 6 years of resident doctor career in China, I went to The University of Melbourne to pursue higher research degree.
  • My PhD project was to investigate the inflammatory mechanism of Parkinson's Disease.
  • We have revealed that meloxicam, a preferentially selective COX-2 inhibitor, attenuates dopaminergic neuronal loss in the substantial nigra pars compacts in LPS-induced rats brain, by inhibiting microglial activation.
  • From my 2nd year on of my PhD, I had switched to study neurogenesis in the adult brains.
  • Employing 6-OHDA lesioned mice and cholecystokinin-1 receptor ablated mice, we have shown neurogenesis is regulated by cellular feedback in the olfactory system.
  • My recent research interest has been focusing on the chemokine-induced pathogenesis and chemokine-regulated neurogenesis in neurodegenerative diseases.