Antibodies

Overview

Antibodies, or immunoglobulins, are glycoproteins produced by B lymphocytes and plasma cells that recognize and bind specific molecular targets called antigens with high affinity and specificity. Each antibody comprises paired heavy and light chains forming variable regions that determine antigen recognition and constant regions that mediate effector functions such as neutralization, opsonization, complement activation, and recruitment of immune cells. The major isotypes, including IgG, IgM, IgA, IgE, and IgD, differ in structure, valency, tissue distribution, and biological role. Beyond their function in humoral immunity, antibodies are foundational reagents and therapeutics: monoclonal antibodies, single-domain and single-chain variable fragment (scFv) constructs, and engineered formats underpin diagnostics, immunoassays, and targeted treatment. Research in this area examines neutralizing antibodies in convalescent plasma against SARS-CoV-2, generation of single-domain antibodies against bacterial pathogens, isolation of human monoclonal scFv antibodies recognizing receptor heteromers, donor-specific anti-HLA antibodies in transplantation, and autoantibodies in hematologic disease, alongside emerging immunoassay and immunogenomic approaches for immunomonitoring in cancer and infection. The journal publishes peer-reviewed work spanning antibody structure, generation, characterization, and application across immunology, infectious disease, hematology, and biochemistry, connecting molecular recognition to diagnostic and therapeutic practice.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 29 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Effect of vitamin D status on a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) and interleukin 6 in patients with acute myeloid leukaemia
  Dina Ashraf Abdelhady et al. · 2025 · European Journal of Medical Research
• Effect of vitamin D status on a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) and interleukin 6 in patients with acute myeloid leukaemia
  2025 · European journal of medical research
• Results of haploidentical transplant in patients with donor-specific antibodies: a survey on behalf of the Spanish Group of Hematopoietic Transplant and Cell Therapy
  2023 · Frontiers in Immunology
• Results of haploidentical transplant in patients with donor-specific antibodies: a survey on behalf of the Spanish Group of Hematopoietic Transplant and Cell Therapy
  R. Bailén et al. · 2023 · Frontiers in Immunology
• Dopamine D2 and Serotonin 5-HT1A Dimeric Receptor-Binding Monomeric Antibody scFv as a Potential Ligand for Carrying Drugs Targeting Selected Areas of the Brain
  2022 · Biomolecules
• CFTR-mediated monocyte/macrophage dysfunction revealed by cystic fibrosis proband-parent comparisons
  2022 · JCI Insight
• Dopamine D2 and Serotonin 5-HT1A Dimeric Receptor-Binding Monomeric Antibody scFv as a Potential Ligand for Carrying Drugs Targeting Selected Areas of the Brain
  Agata Kowalik et al. · 2022 · Biomolecules
• CFTR-mediated monocyte/macrophage dysfunction revealed by cystic fibrosis proband-parent comparisons
  2022 · JCI Insight

A sample of recent works citing this journal's research on Antibodies, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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