2023
Overview
Aggressive chemotherapy is the use of high-intensity cytotoxic drug treatment, often at high doses or in combination regimens, intended to achieve maximal reduction of a cancer's burden. It is typically employed for advanced, rapidly progressing, or treatment-resistant malignancies, and for cancers where the goal is cure or substantial control despite a greater risk of toxicity. Because it targets rapidly dividing cells, aggressive chemotherapy can cause significant side effects, including myelosuppression, gastrointestinal and other organ toxicity, and immune compromise, so its use requires careful patient selection, supportive care, and monitoring. The International Journal of Chemotherapy Research and Practice is a peer-reviewed, open-access journal covering anticancer drug therapy and its clinical application. Its scope is reflected in work on aggressive and difficult malignancies, such as a case report and literature review of primary leiomyosarcoma of the thyroid, a rare and aggressive tumor whose management bears on intensive treatment decisions. A separately listed article on lung cancer with isolated adrenal metastases concerns metastatic disease patterns rather than chemotherapy intensity specifically. This page gathers peer-reviewed, open-access research relevant to cancer chemotherapy and its practice, within which aggressive, high-intensity regimens are one therapeutic strategy.
Research published in this journal
2 peer-reviewed articles, ranked by relevance. Each links to its DOI.
2019