Research Topic · Peer-Reviewed

Celiac Disease

Celiac disease is a chronic immune-mediated enteropathy triggered in genetically predisposed individuals by dietary gluten, the storage protein of wheat, rye, and barley. Ingested gliadin peptides, after deamidation by tissue transglutaminase, are presented in the context of HLA-DQ2 or HLA-DQ8 molecules, provoking a…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 22× across the literature 🗓 Reviewed June 2026

Overview

Celiac disease is a chronic immune-mediated enteropathy triggered in genetically predisposed individuals by dietary gluten, the storage protein of wheat, rye, and barley. Ingested gliadin peptides, after deamidation by tissue transglutaminase, are presented in the context of HLA-DQ2 or HLA-DQ8 molecules, provoking a T-cell-driven inflammatory response that damages the small-intestinal mucosa and causes villous atrophy, crypt hyperplasia, and malabsorption. Presentation ranges from classic gastrointestinal symptoms such as diarrhea, bloating, and weight loss to extraintestinal manifestations including iron-deficiency anaemia, fatigue, osteopenia, and dermatitis herpetiformis, and the condition frequently coexists with other autoimmune disorders such as type 1 diabetes and autoimmune thyroid disease. Diagnosis relies on serology for anti-tissue-transglutaminase and anti-endomysial antibodies together with duodenal biopsy, and the only established treatment is lifelong adherence to a strict gluten-free diet, which permits mucosal healing and symptom resolution. Untreated disease carries long-term risks including persistent nutrient deficiency and small-bowel complications. Research relevant to this area examines the autoimmune and gastrointestinal dimensions of gluten-related and intestinal disorders, gluten-free dietary intervention, and associated polyglandular and nutritional conditions. The journal publishes peer-reviewed research on the immunology, diagnosis, and dietary management of celiac and related gastrointestinal autoimmune disease.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 22 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Celiac Disease, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Inflammation Research.

Journal editorial board
Thomas Boldicke · Germany Graziella Curtale · Italy Frederic Velard · France

This page summarises published research for orientation; it is not medical or professional advice.