Research Topic · Peer-Reviewed

Inflammatory Arthritis

Inflammatory arthritis is a group of disorders in which immune-mediated inflammation of the synovial membrane drives joint pain, swelling, stiffness, and, if uncontrolled, progressive cartilage and bone destruction. It is distinguished from degenerative (mechanical) arthritis by the presence of systemic inflammation…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 14× across the literature 🗓 Reviewed June 2026

Overview

Inflammatory arthritis is a group of disorders in which immune-mediated inflammation of the synovial membrane drives joint pain, swelling, stiffness, and, if uncontrolled, progressive cartilage and bone destruction. It is distinguished from degenerative (mechanical) arthritis by the presence of systemic inflammation, frequently autoimmune in origin. The category includes rheumatoid arthritis, juvenile idiopathic arthritis, the spondyloarthritides including psoriatic arthritis, and crystal-induced arthropathies such as gout, as well as arthritis arising from infection (septic arthritis). The shared pathophysiology involves activation of innate and adaptive immunity, infiltration of the synovium by leukocytes, proliferation of synovial fibroblasts, and release of pro-inflammatory cytokines such as TNF-alpha, interleukin-1, and interleukin-6 that perpetuate joint damage and contribute to extra-articular manifestations. Diagnosis integrates clinical examination, inflammatory markers and autoantibodies, and imaging, while management aims for early control of inflammation to preserve function and prevent disability, increasingly with targeted and biologic disease-modifying therapy. Research in this area spans the cellular events within the inflamed synovium, the genetics of autoimmune susceptibility, cytokine-directed treatment, and clinical studies of juvenile and adult arthritis across diverse populations. The journal publishes peer-reviewed work on the immunological mechanisms, biomarkers, and clinical management of inflammatory joint disease.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 14 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Inflammatory Arthritis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Inflammation Research.

Journal editorial board
Thomas Boldicke · Germany Graziella Curtale · Italy Frederic Velard · France

This page summarises published research for orientation; it is not medical or professional advice.