Research Topic · Peer-Reviewed

Inflammatory Diseases

Inflammatory diseases are conditions in which inflammation, the coordinated response of the immune system to injury, infection, or perceived threat, becomes excessive, chronic, or misdirected and itself drives tissue damage. Acute inflammation is protective and self-limiting, but persistent or dysregulated inflammat…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 15× across the literature 🗓 Reviewed June 2026

Overview

Inflammatory diseases are conditions in which inflammation, the coordinated response of the immune system to injury, infection, or perceived threat, becomes excessive, chronic, or misdirected and itself drives tissue damage. Acute inflammation is protective and self-limiting, but persistent or dysregulated inflammation underlies a wide range of disorders, including autoimmune diseases in which the immune system reacts against self-antigens. Mechanistically, these diseases involve activation of innate and adaptive immune cells and the release of pro-inflammatory mediators, with transcription factors such as NF-κB coordinating cytokine production; genetic susceptibility and environmental triggers interact to determine onset and severity. The processes implicate cytokines including interleukin-6, tumour necrosis factor, and interleukin-1, reactive oxygen species, and downstream effects across multiple organ systems, from skin and joints to kidney and gut. Understanding the molecular pathways of inflammation guides anti-inflammatory and immunomodulatory therapy and the development of biomarkers. Research relevant to this area spans autoimmune disease and the interplay of genes, inflammation, and environment, transcription-factor regulation of pro-inflammatory signalling, systemic inflammatory response models, anti-inflammatory and antioxidant interventions, vagus-nerve modulation of pain-related cytokines, and inflammatory mechanisms in chronic kidney and metabolic disease. The International Journal of Inflammation Research publishes peer-reviewed work on the mechanisms, mediators, and management of inflammatory disease.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 15 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Inflammatory Diseases, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Inflammation Research.

Journal editorial board
Thomas Boldicke · Germany Graziella Curtale · Italy Frederic Velard · France

This page summarises published research for orientation; it is not medical or professional advice.