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Why Do Human Body Systems Go Into Catastrophic System Failure Leading to Diseases -Is the Answer in Science or Nature?

Abstract:

Both the human body and the natural world are governed by multiple complex systems. These systems have feedback loops which is a process in which the outputs of a system are circled back and used as inputs.

Where there are multiple systems, there is always the potential for a catastrophic system failure.

If a system fails in the human body, this can lead to a number of life-threatening and debilitating diseases such as cancer. Diseases such as cancer is in effect, the result of a catastrophic system failure. There are cancer cases in which the root cause of the disease is unknown.

System failure in the human reproductive system can lead to congenital birth defects.

In cases of a system failure leading to congenital birth defects, some of the causal factors are known but in 65% of these cases, the reasons for this reproductive system failure are unexplained.

There are ne...

Creation of Music-Induced Analgesia in Chronic Pain Patients through Endogenous Opioid Production: A Narrative Review

Abstract:

Chronic pain affects over 30% of the global population, and reliance on external drugs for treatment has led to major issues, including the present opioid epidemic. A healthier option is necessary, which is why music therapy’s analgesic effects have been extensively studied within the last 20 years. Not only is music relatively harmless but given that chronic pain patients require repeated treatment, musical intervention is far more accessible and economical. While the mechanisms underlying music-induced analgesia are relatively unclear, the production of endogenous opioids while listening to music through both the descending pain modulatory circuit and the limbic system, is postulated to play this role. This review describes the brain regions and pathways by which music may trigger the release of endogenous opioids such as enkephalins, endorphins, and dynorphins. More importantly, it ...

Loneliness and Bedtime Procrastination: Exploring a Model of Interconnectedness Among Young Adults in Germany

Abstract:

This study aimed to examine the relationship between loneliness and bedtime procrastination in young adults in Germany, offering critical insights into the development and maintenance of both conditions. Specifically, it sought to test a new model that connects these two psychological constructs.

Primary Healthcare Services and Health-Related Quality of Life of Older Persons with Non-Communicable Diseases: A Narrative Literature Review

Abstract:

In response to the rising burden of non-communicable disease (NDC), the World Health Organization (WHO) developed tools to enable early detection and management of NCDs in Primary Healthcare centers (PHC). Globally, the prevalence of NCDs remains alarmingly high with 41 million deaths annually. Of these, 17 million people die before the age of 70, and 86% of these premature deaths occur in low-and middle-income countries. This narrative review aimed to assess the effect of PHC services on health-related quality of life (HRQoL) of older persons with NCDs, to critically analyze the potential of the existing literature in informing improvements in PHC services. We searched various databases (PubMed, Springer, Scopus, and ScienceDirect) for relevant literature. Peer-reviewed articles on the influence of PHC services on HRQoL among older persons with NCDs written and published in English between Januar...

Increased Reaction Vessel Surface Area Decreases the Overall Mortality Rate of Rana catesbeiana Larvae during Chemically Induced Metamorphosis

Abstract:

Stimulating precocious metamorphosis in anuran larvae is an important pedagogical tool for understanding vertebrate development. However, historically, artificially provoking metamorphosis by immersing tadpoles in exogenous inducing agents (e.g., thyroxine, and iodine) compromises the longevity of the experimental animals, resulting in up to 100% mortality within a week. In our undergraduate teaching lab, we house our experimental tadpoles in circular glass dishes having a surface area of 182 cm². Over the past four academic years this lab was performed, we observed 100% mortality of experimental animals within 10, 12, or 15 days when treated with 10^-5 M, 10^-6 M, or 10^-7 M thyroxine, respectively. Here, we investigated whether increasing the surface area to 413 cm² using square glass dishes would reduce the mortality of...

RBM45: Molecular, Cellular, and Evolutionary Biology

Abstract:

This article surveys RBM45 from molecular function and RNA binding to cellular roles and evolutionary conservation. It summarizes emerging links to neurobiology and disease, and highlights tools and models to probe RBM45 biology.

Climate Change Reduces Darling River Water Levels by Decreasing Eastern Australian Rainfall

Abstract:

Significantly decreased rainfall run-off into the dams that feed the Darling River in eastern Australia during the Millennium (1997–2009) and Tinderbox (2017 –2019) Droughts coincided with reduced river levels along the Darling River. The rainfall reduction was due to accelerated global warming since the mid-late 1990s. During this period, unmonitored river water extraction from the streams that feed the Darling River was diverted to crops, on-farm dams, and to storage in the Menindee Lake system. This practice exacerbated the effect of the two droughts because streamflow that reaches the Darling River ceased in several upstream rivers, and in the Darling River. Using Darling River height levels, before and after the mid-late 1990s, it is shown that global warming is the key factor reducing Darling River levels in the last 53 years, even allowing for river water diversion and extraction. Between the periods 1972-1997 and 1998-2024 the Darling ...

COVID-19-Induced Changes in the Fibrin Network of Pulmonary and Renal Microthrombi

Abstract:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection often causes coagulation disorders that affect highly vascularized organs, such as the lungs and kidneys.

Delving into the Ideas of Charles Darwin: A Study of His Pre-Beagle Musings, Beagle Expedition, and Subsequent Developments

Abstract:

Charles Darwin's exploration of the Galápagos Islands in 1835 and his subsequent formulation of the theory of evolution in 1839 were significantly influenced by his observations of land-birds, including finches, larks, owls, and mockingthrushes. Despite a primary focus on geology during his voyage on the HMS Beagle, Darwin meticulously documented various species in his field notebooks. Early observations during his youth at Edinburgh University and the Beagle expedition reflected Darwin's growing curiosity about species variation. However, it was not until his return to England and his interaction with ornithologist John Gould that Darwin began to recognize the significance of the finches he had observed in the Galápagos. This review synthesizes existing literature on Darwin's transition from geological interests to his groundbreaking insights into evolution. By examining primary sources, historical interpretations, and contemporary analyses, this paper highligh...

On Tesla-inspired Extended Quantum-Holographic Framework for Reprogramming Macro-Quantum Correlations of Individual and Collective Consciousness

Abstract:

Nikola Tesla's visions and inventions realized in his controlled altered states of consciousness were considered previously as manifestations of his meditative insights within an extended framework of quantum-holographic macroquantum correlations of individual & collective consciousness. This Tesla-inspired paper now focuses on related psychosomatic aspects of quantum entropy & entanglement, and consequences on the usually observable biological arrow of time & spiritual-informational time reversal. Finally we discuss spiritual-informational implications for free will and individual and collective consciousness reprogramming.