Aims & Scope
Journal of Organ Transplantation (JOT) publishes rigorous research advancing the science, clinical practice, and bioengineering of solid organ transplantation, with emphasis on immunological mechanisms, surgical innovation, organ preservation technologies, and regenerative approaches to transplant medicine.
Core Research Domains Tier 1
Transplant Immunology & Rejection
- Immunosuppressive therapy protocols and novel immune modulation strategies
- Acute and chronic rejection mechanisms at cellular and molecular levels
- Tolerance induction and regulatory T-cell therapies
- Histocompatibility testing, HLA matching, and biomarker discovery
- Antibody-mediated rejection and desensitization protocols
- Innate and adaptive immune responses to allografts
"Novel biomarkers for early detection of antibody-mediated rejection in kidney transplant recipients: a multicenter cohort study"
Organ Preservation & Perfusion Technologies
- Static cold storage optimization and preservation solutions
- Machine perfusion techniques (hypothermic, normothermic, subnormothermic)
- Organ viability assessment and quality prediction models
- Ischemia-reperfusion injury mechanisms and mitigation strategies
- Extended criteria donor organ utilization
- Transportation logistics and time-sensitive preservation protocols
"Normothermic machine perfusion extends viable preservation time for marginal liver grafts: outcomes from a randomized controlled trial"
Clinical Transplantation & Surgical Innovation
- Solid organ transplantation procedures (heart, liver, kidney, lung, pancreas, intestine)
- Living donor and deceased donor surgical techniques
- Minimally invasive and robotic-assisted transplant surgery
- Multi-organ transplantation and composite tissue allotransplantation
- Pre-transplant recipient evaluation and risk stratification
- Intraoperative monitoring and perioperative management
"Robotic-assisted living donor nephrectomy: 5-year outcomes comparing surgical complications and graft function"
Post-Transplant Outcomes & Complications
- Long-term graft survival analysis and predictive modeling
- Infectious complications in immunosuppressed recipients
- Post-transplant malignancies and cancer surveillance
- Cardiovascular and metabolic complications following transplantation
- Chronic kidney disease in non-renal transplant recipients
- Quality of life, psychosocial outcomes, and patient-reported measures
"Incidence and risk factors for post-transplant lymphoproliferative disorder in solid organ transplant recipients: a 15-year registry analysis"
Secondary Focus Areas Tier 2
Regenerative Medicine & Tissue Engineering
Stem cell-based organ repair, 3D bioprinting of transplantable tissues, scaffold development, and decellularization/recellularization techniques for organ engineering.
Gene & Cell Therapy in Transplantation
Gene editing approaches (CRISPR/Cas9) to improve graft compatibility, ex vivo gene therapy for donor organs, and cellular therapies to enhance transplant outcomes.
Xenotransplantation
Cross-species organ transplantation, genetic modification of donor animals, immunological barriers to xenografts, and regulatory/ethical frameworks for clinical translation.
Transplant Pharmacology
Immunosuppressive drug pharmacokinetics/pharmacodynamics, therapeutic drug monitoring, drug-drug interactions, and novel immunosuppressive agents in development.
Organ Allocation & Policy
Allocation algorithms, equity in organ distribution, donor registry optimization, ethical frameworks for organ allocation, and health economics of transplantation.
Transplant Infectious Diseases
Donor-derived infections, opportunistic infections in immunosuppressed recipients, antimicrobial prophylaxis strategies, and viral reactivation management.
Emerging Research Frontiers Tier 3
Artificial Intelligence in Transplantation
Machine learning for graft survival prediction, AI-assisted organ matching, computer vision for histopathology analysis, and predictive analytics for rejection risk.
Organoid & Organ-on-Chip Technologies
Miniaturized organ models for transplant research, microfluidic systems for studying organ function, and preclinical testing platforms for immunosuppressive agents.
Microbiome & Transplantation
Gut microbiome influence on transplant outcomes, microbiome modulation strategies, and microbial biomarkers for rejection or infection risk.
Article Types & Editorial Priorities
Expedited Review (4-6 weeks)
- Original Research Articles
- Systematic Reviews & Meta-Analyses
- Novel Methods & Protocols
- Randomized Controlled Trials
- Large Cohort Studies (n>500)
Standard Review (6-8 weeks)
- Short Communications
- Technical Notes
- Data Descriptors
- Clinical Perspectives
- Translational Research Reports
Selective Acceptance
- Single-Center Case Reports
- Opinion Pieces
- Narrative Reviews (non-systematic)
- Commentaries
Editorial Standards & Requirements
Reporting Guidelines
CONSORT for trials, STROBE for observational studies, PRISMA for systematic reviews, ARRIVE for animal studies
Data Availability
Raw data deposition in public repositories required for all original research articles
Ethics Approval
IRB/ethics committee approval mandatory for human subjects research; IACUC approval for animal studies
Preprint Policy
Preprints on recognized servers (medRxiv, bioRxiv) accepted; must be disclosed at submission
Authorship
ICMJE criteria enforced; CRediT taxonomy recommended for author contributions
Conflicts of Interest
Full disclosure of financial and non-financial competing interests required from all authors
Ready to Submit?
If your research advances transplantation science, clinical practice, or bioengineering within our scope, we invite your submission.
Submit Your ManuscriptQuestions about scope fit? Contact our editorial office at [email protected]
